SymbolSION
NameSIONNA THERAPEUTICS, INC.
SectorHEALTH CARE
RegionNorth America
IndustryBiotechnology: Pharmaceutical Preparations
Address21 HICKORY DRIVE,SUITE 500, WALTHAM, Massachusetts, 02451, United States
Telephone617-819-2020
Fax
Email
Websitehttps://www.sionnatx.com
IncorporationUNDEFINED
Incorporated On
Employees
Fiscal Year
Public Since
ExchangesNASDAQ
Auditor
Audit StatusNOT PROVIDED
Reporting Status
CIK0002036042
Description

Sionna Therapeutics is a clinical-stage biopharmaceutical company on a mission to revolutionize the treatment paradigm for cystic fibrosis (CF) patients. The company focuses on developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefits to CF patients. Their goal is to deliver differentiated medicines that can restore CFTR function as close to normal as possible by directly stabilizing CFTRs nucleotide-binding domain 1 (NBD1). Sionna is currently conducting Phase 1 trials for two highly potent NBD1 stabilizers and developing a portfolio of complementary CFTR modulators designed to work synergistically with their NBD1 stabilizers to improve CFTR function, as observed in preclinical models.

Additional info from NASDAQ:
Sionna Therapeutics is a clinical-stage biopharmaceutical company on a mission to revolutionize the treatment paradigm for cystic fibrosis (CF) patients. The company focuses on developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefits to CF patients. Their goal is to deliver differentiated medicines that can restore CFTR function as close to normal as possible by directly stabilizing CFTRs nucleotide-binding domain 1 (NBD1). Sionna is currently conducting Phase 1 trials for two highly potent NBD1 stabilizers and developing a portfolio of complementary CFTR modulators designed to work synergistically with their NBD1 stabilizers to improve CFTR function, as observed in preclinical models.

2026-08-27 20:45

INVESTIGATION ALERT: Investigation Launched into Sionna Therapeutics, Inc., Robbins Geller Rudman & Dowd LLP Attorneys Encourage Investors and Potential Witnesses to Contact Law Firm - SION

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2026-08-27 20:32

INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Sionna Therapeutics, Inc. - SION

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2026-08-20 02:22

Robbins LLP Reminds Stockholders it is Investigating the Recent Stock Drop of Sionna Therapeutics

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2026-08-19 17:12

Sionna Therapeutics (SION) Securities Investigation Notice - Levi & Korsinsky

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2026-08-19 11:55

Investigation Launched into Sionna Therapeutics, Inc. (SION), Robbins Geller Rudman & Dowd LLP Attorneys Encourage Investors and Potential Witnesses to Contact Law Firm

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2026-08-18 15:00

Securities Fraud Investigation Into Sionna Therapeutics, Inc. (SION) Announced – Shareholders Who Lost Money Urged To Contact Glancy Prongay Wolke & Rotter LLP, a Leading Securities Fraud Law Firm

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2026-08-18 13:00

Sionna Therapeutics, Inc. (SION) Shareholders Who Lost Money – Contact Law Offices of Howard G. Smith About Securities Fraud Investigation

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2026-08-17 21:58

Securities Fraud Investigation Into Sionna Therapeutics, Inc. (SION) Announced – Shareholders Who Lost Money Urged to Contact The Law Offices of Frank R. Cruz

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2026-08-17 20:20

Robbins LLP is Investigating the Recent Stock Drop of Sionna Therapeutics; Contact the Firm for Information

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2026-08-14 14:30

SION Investor Alert: Levi & Korsinsky Notifies Investors of Investigation Into Sionna Therapeutics (SION)

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Trial ID Title Phase Indication Status Start Date Completion Date Source
NCT07108153 Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacodynamics, … Phase2 Cystic Fibrosis (CF) Active_Not_Recruiting 2025-11-03 2026-07-01 ClinicalTrials.gov
NCT07035990 Safety, Tolerability, and Pharmacokinetics of Multiple Dose Combinations of SIO… Phase1 Cystic Fibrosis (CF) Recruiting 2025-07-23 2026-06-01 ClinicalTrials.gov
Total clinical trials: 2
Product Name Type Development Stage Therapeutic Area Study Status Trial ID
Placebo-to-match SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
Placebo-to-match SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
Placebo-to-match SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
Placebo-to-match SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
Placebo-to-match SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
Placebo-to-match SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
Placebo-to-match SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
Placebo-to-match SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) ACTIVE_NOT_RECRUITING NCT07108153
Placebo SION-109 Other Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
Placebo SION-2222 Other Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
Placebo SION-451 Other Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
SION-109 Other Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
SION-2222 Other Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
SION-451 Other Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
Placebo-to-match SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) RECRUITING NCT07108153
SION-719 Other Phase PHASE2 Cystic Fibrosis (CF) RECRUITING NCT07108153
Placebo-to-match SION-719 DRUG Phase PHASE2 Cystic Fibrosis (CF) RECRUITING NCT07108153
SION-719 DRUG Phase PHASE2 Cystic Fibrosis (CF) RECRUITING NCT07108153
Placebo SION-109 DRUG Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
Placebo SION-2222 DRUG Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
Placebo SION-451 DRUG Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
SION-109 DRUG Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
SION-2222 DRUG Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
SION-451 DRUG Phase PHASE1 Cystic Fibrosis (CF) RECRUITING NCT07035990
Total products: 32