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  • News bot June 30, 2026, 11:33 a.m.

    📋 PACIRA BIOSCIENCES, INC. (PCRX) - Clinical Trial Update

    Filing Date: 2026-06-30

    Accepted: 2026-06-30 07:31:57

    Event Type: Clinical Trial Update

    Event Details:

    PACIRA BIOSCIENCES, INC. (PCRX) Announces Clinical Trial Update PACIRA BIOSCIENCES, INC. (PCRX) provided an update on its clinical development programs. Clinical Development Highlights:
    • Drug Program: leader
    • Diseases/Conditions: its commitment to deliver innovative
    • Collaboration: FDA
      • targeting nerve location by conducting electrical nerve stimulation from a compatible 3rd party nerve stimulator. In addition, patients treated with iovera° after total knee replacement surgery experienced more than 1.5 times improvement in knee symptoms and function versus controls at 6 and 12 weeks (KOOS symptom score)1,2, significant reductions in both pain severity and the extent to which pain interfered with daily activities at early follow-up (PROMIS pain intensity and pain interference scores)1, and a 45% reduction in opioid consumption over 12 weeks post-surgery1. The iovera° system is not indicated for treatment of central nervous system tissue. 1 Dasa V et al. Knee. 2016

    🔬 Clinical Development Pipeline (PACIRA BIOSCIENCES, INC.):

    Product Type Development Stage Therapeutic Area Source
    Bupivacaine liposome injectable suspension (LIA) Other Phase PHASE4 Total Knee Arthroplasty ClinicalTrials.gov
    EXPAREL Other Phase PHASE4 Retraction of Colostomy ClinicalTrials.gov
    Bupivacaine liposome injectable suspension (IPSA block) Other Phase PHASE4 Total Knee Arthroplasty ClinicalTrials.gov
    Treatment for Knee OA Drug Preclinical Knee Osteoarthritis ClinicalTrials.gov
    Thoracic epidural analgesia (bupivacaine) Other Phase PHASE3 Surgery ClinicalTrials.gov
    Exparel Injectable Product Other Phase PHASE1 Breast Augmentation ClinicalTrials.gov
    Iovera Medial Branch Cryoneurolysis Other Approved Low Back Pain, Chronic ClinicalTrials.gov
    Radiofrequency ablation (RFA) Other Approved Low Back Pain, Chronic ClinicalTrials.gov
    Placebo Other Phase PHASE3 Glenohumeral Osteoarthritis ClinicalTrials.gov
    ZILRETTA Other Phase PHASE3 Glenohumeral Osteoarthritis ClinicalTrials.gov
    Liposomal bupivacaine Other Phase PHASE3 Surgery ClinicalTrials.gov
    Local Infiltration Analgesia (LIA) Other Phase PHASE4 Total Knee Arthroplasty ClinicalTrials.gov
    Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA Other Phase PHASE4 Total Knee Arthroplasty ClinicalTrials.gov
    Cryoneurolysis Other Approved ACL Repair ClinicalTrials.gov
    Cryo-Touch III Device Device Approved Entrapment Neuropathy ClinicalTrials.gov
    IV morphine sulfate or Sponsor-approved equivalent Other Phase PHASE4 Retraction of Colostomy ClinicalTrials.gov
    EXPAREL 266 mg Other Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    EXPAREL 133 mg Other Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    EXPAREL 67 mg Other Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    Bupivacaine HCl Other Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    SKY0402 Other Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    EXPAREL Infiltration Other Phase PHASE4 Pain ClinicalTrials.gov
    Bupivacaine SNB Other Phase PHASE4 Pain ClinicalTrials.gov
    Bupivacaine Hydrochloride Other Phase PHASE1 Breast Augmentation ClinicalTrials.gov
    Bupivacaine supraclavicular block Other Phase PHASE4 Hand Injuries ClinicalTrials.gov
    Exparel Forearm block Other Phase PHASE4 Hand Injuries ClinicalTrials.gov
    Questionnaire and Physical Exam Other Preclinical Postoperative Pain ClinicalTrials.gov
    EXPAREL (bupivacaine liposome injectable suspension) Other Phase PHASE4 Bowel Obstruction ClinicalTrials.gov
    IV morphine sulfate Other Phase PHASE4 Bowel Obstruction ClinicalTrials.gov
    Group 2 EXPAREL Other Phase PHASE4 Retraction of Colostomy ClinicalTrials.gov
    Group 1 Standard of Care Other Phase PHASE4 Retraction of Colostomy ClinicalTrials.gov
    bupivacaine liposome extended-release injectable suspension Other Phase PHASE4 Bowel Obstruction ClinicalTrials.gov
    morphine sulfate Other Phase PHASE4 Bowel Obstruction ClinicalTrials.gov
    On-Q Pain Ball Other Phase PHASE4 Obesity ClinicalTrials.gov
    Infiltration - EXPAREL Other Phase PHASE4 Mammoplasty ClinicalTrials.gov
    Instillation - EXPAREL Other Phase PHASE4 Mammoplasty ClinicalTrials.gov
    Cryotherapy for the utilization of wrinkle reduction (iovera) Drug Preclinical Wrinkles ClinicalTrials.gov
    iovera Other Approved Forehead Wrinkles ClinicalTrials.gov
    Treatment with CryoTouch III Device Drug Preclinical Frown Lines ClinicalTrials.gov
    Treatment with CryoTouch IV Drug Preclinical Frown Lines ClinicalTrials.gov
    Cryo-Touch II Other Phase PHASE2 Facial Wrinkles ClinicalTrials.gov
    Cryo-Touch III Other Phase PHASE2 Facial Wrinkles ClinicalTrials.gov
    Bupivacaine block in shoulder surgery Procedure Approved Injury of Shoulder Region ClinicalTrials.gov
    Exparel block in arthroscopic shoulder surgery Procedure Approved Injury of Shoulder Region ClinicalTrials.gov
    Continuous Perineural Ropivicaine Infusion Other Phase PHASE4 Postoperative Pain ClinicalTrials.gov
    Liposomal Bupivacaine Infiltration Other Phase PHASE4 Postoperative Pain ClinicalTrials.gov
    MRI Other Preclinical Hematoma ClinicalTrials.gov
    iovera° Other Approved Anterior Cruciate Ligament Reconstruction ClinicalTrials.gov
    Bupivacaine Hcl 0.25% Inj Other Phase PHASE4 Post Operative Pain ClinicalTrials.gov
    Exparel 266 MG Per 20 ML Injection Other Phase PHASE4 Post Operative Pain ClinicalTrials.gov
    Ropivacaine Other Phase PHASE2 Chronic Shoulder Pain ClinicalTrials.gov
    EXPAREL® infiltration Other Preclinical Pain Management ClinicalTrials.gov
    Opioids delivered through PCA Other Preclinical Pain Management ClinicalTrials.gov
    EXPAREL 13.3Mg/mL Suspension for Injection Other Phase PHASE3 Bunion ClinicalTrials.gov
    Liposome bupivacaine + bupivacaine Other Phase PHASE2 Dupuytren's Contracture of the Hand (Viking's Disease) ClinicalTrials.gov
    Liposome bupivacaine Other Phase PHASE2 Hallux Valgus (Bunions) ClinicalTrials.gov
    bupivacaine liposome injectable suspension Other Phase PHASE3 Pain ClinicalTrials.gov
    Bupivacaine liposome Other Phase PHASE3 Dental Pain ClinicalTrials.gov
    Tranexamic Acid Other Phase PHASE2 Total Knee Arthroplasty ClinicalTrials.gov
    DepoTXA Other Phase PHASE2 Total Knee Arthroplasty ClinicalTrials.gov
    Bupivacaine Other Phase PHASE4 Pain ClinicalTrials.gov
    Standard Bupivacaine Other Phase PHASE4 Male Infertility ClinicalTrials.gov
    0.5% Bupivacaine HCl Other Phase PHASE3 Postoperative Pain Management ClinicalTrials.gov
    Exparel + Bupivacaine Other Phase PHASE4 C-Section ClinicalTrials.gov
    Mid-dose SKY0402 + bupivacaine HCl Other Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    SKY0402 + bupivacaine HCl Other Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    Bupivacaine FNB Other Phase PHASE4 Pain ClinicalTrials.gov
    Intrathecal morphine injection Other Phase PHASE4 Pain ClinicalTrials.gov
    EXPAREL 40 mL Other Phase PHASE4 Postsurgical Pain ClinicalTrials.gov
    EXPAREL 20 mL Other Phase PHASE4 Postsurgical Pain ClinicalTrials.gov
    EXPAREL and bupivacaine HCl Other Phase PHASE4 Postoperative Pain Management ClinicalTrials.gov
    Symptom Questionnaire Other Phase PHASE3 Malignant Neoplasms of Female Genital Organs ClinicalTrials.gov
    Pill Diary Other Phase PHASE3 Malignant Neoplasms of Female Genital Organs ClinicalTrials.gov
    Oxycodone Other Phase PHASE3 Malignant Neoplasms of Female Genital Organs ClinicalTrials.gov
    Standard of Care Other Phase PHASE4 Postoperative Pain Management ClinicalTrials.gov
    EXPAREL and Bupivacaine Other Phase PHASE4 Postoperative Pain Management ClinicalTrials.gov
    Triamcinolone Acetonide Extended-Release Injectable Suspension Other Phase PHASE1 Osteoarthritis, Knee ClinicalTrials.gov
    Bupivacaine hydrochloride (HCl) Other Phase PHASE4 Pain, Postoperative ClinicalTrials.gov
    Depofoam bupivacaine Other Phase PHASE4 Pain, Postoperative ClinicalTrials.gov
    Exparel TAP + multi-modal pain regimen Other Phase PHASE4 Elective Cesarean Section ClinicalTrials.gov
    150 mcg Duramorph + multi-modal pain regimen Other Phase PHASE4 Elective Cesarean Section ClinicalTrials.gov
    50 mcg Duramorph+ EXPAREL + multi-modal pain regimen Other Phase PHASE4 Elective Cesarean Section ClinicalTrials.gov
    Normal Saline Other Phase PHASE1 Pain, Postoperative ClinicalTrials.gov
    FX301 Other Phase PHASE1 Pain, Postoperative ClinicalTrials.gov
    Cryoanalgesia (iovera°®) Other Approved Morton's Neuroma ClinicalTrials.gov
    ioveraº sham Other Approved Post-Operative Pain Management ClinicalTrials.gov
    ioveraº Other Approved Post-Operative Pain Management ClinicalTrials.gov
    Sham cryoneurolysis procedure Procedure Approved Mastectomy ClinicalTrials.gov
    Cryoneurolysis (active) Other Approved Mastectomy ClinicalTrials.gov
    FX006 Other Phase PHASE2 Trochanteric Bursitis ClinicalTrials.gov
    FX006 32 mg Other Phase PHASE2 Osteoarthritis, Hip ClinicalTrials.gov
    TAcs 40 mg Other Phase PHASE2 Osteoarthritis of the Shoulder ClinicalTrials.gov
    TCA IR 40 mg Other Phase PHASE2 Osteoarthritis of the Knee ClinicalTrials.gov
    TCA IR 40 Other Phase PHASE2 Osteoarthritis of the Knee ClinicalTrials.gov
    iovera° Sham Other Approved Arthritis of the Knee ClinicalTrials.gov
    Sham Comparator Other Approved Knee Osteoarthritis ClinicalTrials.gov
    FX006 16 mg Other Phase PHASE2 Osteoarthritis of the Knee ClinicalTrials.gov
    FX006 40 mg Other Phase PHASE2 Osteoarthritis of the Knee ClinicalTrials.gov
    FX006 10 mg Other Phase PHASE2 Osteoarthritis of the Knee ClinicalTrials.gov
    Treatment with Cryo-Touch III device Drug Approved Upper Limb Spasticity ClinicalTrials.gov
    Device: Cryo-Touch III Study treatment at Day 0. Drug Approved Occipital Neuralgia ClinicalTrials.gov
    FX006 60 mg Other Phase PHASE2 Osteoarthritis of the Knee ClinicalTrials.gov
    TCA IR Other Phase PHASE2 Osteoarthritis of the Knee ClinicalTrials.gov
    Placebo 2 (Diluent) Other Phase PHASE1 Osteoarthritis, Knee ClinicalTrials.gov
    Placebo 1 (Carrier) Other Phase PHASE1 Osteoarthritis, Knee ClinicalTrials.gov
    FX005 Other Phase PHASE1 Osteoarthritis, Knee ClinicalTrials.gov
    Liposomal bupivacaine (LB, Exparel) Other Phase PHASE4 Adolescent Idiopathic Scoliosis ClinicalTrials.gov
    Methadone Other Phase PHASE4 Adolescent Idiopathic Scoliosis ClinicalTrials.gov
    Radiofrequency ablation Other Approved Low Back Pain ClinicalTrials.gov
    iovera system Other Approved Low Back Pain ClinicalTrials.gov
    Bupivacain Other Phase PHASE2 Back Pain ClinicalTrials.gov
    Acetaminophen 500Mg Cap Other Preclinical ACL Tear ClinicalTrials.gov
    Tramadol Other Preclinical ACL Tear ClinicalTrials.gov
    Acetaminophen Other Preclinical ACL Tear ClinicalTrials.gov
    Celecoxib Other Preclinical ACL Tear ClinicalTrials.gov
    Liposomal Bupivacaine 13.3 Other Phase PHASE1 Healthy ClinicalTrials.gov
    FX201 Other Phase PHASE1 Osteoarthritis, Knee ClinicalTrials.gov
    EXPAREL 1.3 % in 20 ML Injection Other Phase PHASE4 Rotator Cuff Tear ClinicalTrials.gov
    Bupivacaine liposome injectable suspension 133 mg Other Phase PHASE3 Bunionectomy ClinicalTrials.gov
    Bupivacaine liposome injectable suspension 266 mg Other Phase PHASE3 Bunionectomy ClinicalTrials.gov
    Sham Cryoanalgesia Other Approved Postoperative Pain ClinicalTrials.gov
    Cryoanalgesia Other Approved Postoperative Pain ClinicalTrials.gov
    No cryoneurolysis Other Approved Degenerative Joint Disease of Shoulder ClinicalTrials.gov
    Local Infiltration Analgesia (LIA) of EXPAREL Other Approved Total Knee Arthroplasty ClinicalTrials.gov
    Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL Other Approved Total Knee Arthroplasty ClinicalTrials.gov
    Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL Other Approved Total Knee Arthroplasty ClinicalTrials.gov
    an open surgery for abdominal hernia repair Procedure Phase PHASE4 Pain ClinicalTrials.gov
    laparoscopic abdominal hernia repair Other Phase PHASE4 Pain ClinicalTrials.gov
    Ketorolac Other Phase PHASE4 Pain ClinicalTrials.gov
    Thoracic epidural analgesia Other Phase PHASE4 Laparotomy ClinicalTrials.gov
    Continuous popliteal nerve block with unencapsulated bupivacaine Other Phase PHASE4 Moderate-to-severely Painful Ankle Surgery ClinicalTrials.gov
    Adductor canal nerve block with exclusively unencapsulated bupivacaine Other Phase PHASE4 Moderate-to-severely Painful Ankle Surgery ClinicalTrials.gov
    Popliteal nerve block with exclusively unencapsulated bupivacaine Other Phase PHASE4 Moderate-to-severely Painful Ankle Surgery ClinicalTrials.gov
    Continuous popliteal nerve block with normal saline Other Phase PHASE4 Moderate-to-severely Painful Ankle Surgery ClinicalTrials.gov
    Adductor canal nerve block including liposomal bupivacaine Other Phase PHASE4 Moderate-to-severely Painful Ankle Surgery ClinicalTrials.gov
    Popliteal nerve block including liposomal bupivacaine Other Phase PHASE4 Moderate-to-severely Painful Ankle Surgery ClinicalTrials.gov
    Triamcinolone Acetonide Other Phase PHASE2 Osteoarthritis of Hip ClinicalTrials.gov
    0.25% bupivacaine (HCl): 30 ml Other Phase PHASE3 Total Ankle Arthroplasty ClinicalTrials.gov
    0.25% bupivacaine (HCl): 50 ml Other Phase PHASE3 Total Ankle Arthroplasty ClinicalTrials.gov
    ioveraº system Other Preclinical Pain Management Improvement ClinicalTrials.gov
    Enekinragene Inzadenovec (PCRX-201) Other Phase PHASE2 Osteoarthritis (OA) of the Knee ClinicalTrials.gov
    sham iovera° system treatment Drug Approved Spasticity, Cerebral or Spinal Condition ClinicalTrials.gov
    iovera° system Other Approved Spasticity, Cerebral or Spinal Condition ClinicalTrials.gov
    Best Practices Other Phase PHASE3 Knee Osteoarthritis ClinicalTrials.gov
    Pain Coping Skills Training Other Phase PHASE3 Knee Osteoarthritis ClinicalTrials.gov
    Nerve Procedure with nerve ablation Procedure Phase PHASE3 Knee Osteoarthritis ClinicalTrials.gov
    Nerve Procedure with long acting blocks Procedure Phase PHASE3 Knee Osteoarthritis ClinicalTrials.gov
    Intra-Articular Injection Other Phase PHASE3 Knee Osteoarthritis ClinicalTrials.gov
    Duloxetine Other Phase PHASE3 Knee Osteoarthritis ClinicalTrials.gov
    Pecs blocks DEVICE Phase PHASE3 Mammaplasty ClinicalTrials.gov
    Breast Reconstruction (Mammaplasty) PROCEDURE Phase PHASE3 Mammaplasty ClinicalTrials.gov
    MyoScience Tissue Remodeling Device DEVICE Phase PHASE1 Facial Rhytides ClinicalTrials.gov
    SKY0402 300mg in hepatically impaired patients DRUG Phase PHASE1 Pain ClinicalTrials.gov
    SKY0402 300mg in healthy patients DRUG Phase PHASE1 Pain ClinicalTrials.gov
    Bupivacaine via epidural DRUG Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    Fentanyl via PCA DRUG Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    High Dose SKY0402 DRUG Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    Low Dose SKY0402 DRUG Phase PHASE2 Postoperative Pain ClinicalTrials.gov
    DepoDur (extended-release epidural morphine) DRUG Phase PHASE1 Postoperative Pain ClinicalTrials.gov
    Placebo tablet DRUG Phase PHASE1 Postoperative Pain ClinicalTrials.gov
    Placebo injection DRUG Phase PHASE1 Postoperative Pain ClinicalTrials.gov
    Moxifloxacin 400mg DRUG Phase PHASE1 Postoperative Pain ClinicalTrials.gov
    Intrathecal cytarabine (also known as ara-C) DRUG Phase PHASE4 Meningeal Neoplasms ClinicalTrials.gov
    Intrathecal methotrexate DRUG Phase PHASE4 Meningeal Neoplasms ClinicalTrials.gov
    Intrathecal (injected into the spinal fluid) DepoCyt DRUG Phase PHASE4 Meningeal Neoplasms ClinicalTrials.gov

    💼 Business Developments:

    • Partnership
    • Acquisition
    • Licensing: Not available
    • Regulatory Approval
    • Executive Changes: Not available

    Structured Data:

    • Company Name: PACIRA BIOSCIENCES, INC.
    • Ticker Symbol: PCRX

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